Inadequate tissue perfusion leads to inadequate oxygen concentration within the tissues resulting in development of hypoxia. Matsumoto et al, in their review on disturbance of microcirculation due to unhealthy lifestyle, hypothesize that unhealthy lifestyle first causes disturbance of the microcirculation, prompting opening of arteriovenous shunts and increasing bypassing of blood. This prevents the delivery of glucose and insulin to cells of peripheral tissues, causing apparent reduction of insulin sensitivity. Disturbance of the microcirculation also causes oxidative stress in peripheral tissues by inducing ischemia and hypoxia. This oxidative stress is considered to further exacerbate reduction of insulin sensitivity.
Role of Vitamin K2-7 in improving insulin sensitivity :
Vitamin K2-7 reduces blood sugar and improves insulin sensitivity. People with a higher dietary intake of vitamin K are significantly less likely to develop Type 2 diabetes.
Vitamin K2-7 helps in the control of diabetes and insulin sensitivity by :
Reducing progression of insulin resistance.
Improving insulin sensitivity.
Reducing the risk of type 2 diabetes.
Carboxylating MGP, a known inhibitor of arterial calcification.
Osteocalcin, a Vitamin K dependant protein, has been shown to regulate glucose homeostasis
A study was performed by Yoshida et al.  in a randomized, double blind controlled trial on 355 men & women aged 60-80 years to check the effect of Vitamin K supplementation on insulin resistance. Vitamin K was given in a dose of 500 µg/day for 36 months. It was observed that vitamin K supplementation reduced progression of insulin resistance.
It was observed that the effect was statistically significantly lower among men in the supplement group versus the men in the control group. It can be concluded that supplementation of Vitamin K reduces progression of insulin resistance.
In another study by Hosanna et. al. titled 'Vitamin K2 Supplementation Improves Insulin Sensitivity via Osteocalcin Metabolism: A Placebo Controlled Trial', role of vitamin K2 supplementation in β-cell function and/or insulin sensitivity in healthy young male volunteers was studied. The volunteers received 30 mg of vitamin K2 thrice in day for 4 weeks. It was observe that Vitamin K2 supplementation significantly increased the insulin sensitivity index in healthy young men which seems to be related to increased cOC.
In a study done by Joline WJ et. al.  on 38,094 Dutch men & women aged 20-70 years, to investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes.
Following conclusions were drawn from the study:
With each 10 µg increment of menaquinone intake, a linear, inverse association with risk of type 2 diabetes was observed.
The intake of Menaquinones reduces the risk of type 2 diabetes and helps in relieving Insulin Resistance.
In yet another study by Mathieu Ferron et.al.  titled 'Osteocalcin differentially regulates β-cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice', the action of osteocalcin on ß-cells and adipocytes at same concentration and Dose osteocalcin regulate energy metabolism was analyzed. And it was concluded that-
Picomolar amounts of osteocalcin are sufficient to regulate the expression of the Insulin Genes and ß-cell proliferation markers.
Nanomolar amounts of osteocalcin up-regulate adiponectin.
Osteocalcin significantly weaken the deleterious effect on body mass and glucose metabolism in an animal model.
In an unpublished animal study by Viridis group of researchers, it has been observed that Vitamin K2-7 helps in reducing blood sugar within 12 days. This has been patented in PCT/IN2010/000143 and PCT/IN2011/000751.
Complications in patients of Type II Diabetes Mellitus
Low energy levels
Vitamin K2-7 addresses these complications as an effective biofactor.