Viridis BioPharma has advanced the science and understanding of vitamin K2 with extensive research on its production and applications. We have discovered several novel and critical functions of Vitamin K2 in the body and now have 3 PCT patent applications filed, as well as 2 process patents.
TREATMENT OF HUMAN DISEASE CONDITIONS AND DISORDERS USING VITAMIN K ANALOGUES AND DERIVATIVES (PCT/IN2008/000465)
The present invention is related to the therapeutic uses of vitamin K, its analogues and derivatives and vitamin K activity synthesized molecules to improve blood perfusion and ameliorate hypoxia for the prevention and/or treatment of chronic venous insufficiencies and consequent diverse complications such as venous and lymphatic oedema, melanization, paper – money skin, desquamation, restless leg syndrome, muscle cramps, purpuric petechiae, spider - web phlebomegaly, heaviness of legs, paresthesiae and lower limb nerve pain, pooling of blood in inferior limbs and reduced venous return, venous stasis, orthostatic intolerance, thrombophlebitis and thrombus formation in veins and embolism thereof resulting in cardio pulmonary vascular events.
The invention relates to vitamin K, its derivatives and combinations to increase the energy levels in diverse disease states and life style disorders, which are characterized by low energy level due to inadequate VO2max and pO2 and low availability of ATP molecules. VO2max, peak oxygen uptake, is intimately connected to several diseases and life style disorders such as Metabolically Obese but Normal Weight (MONW), Overweight / Obese, diabetes mellitus, coronary artery disease, hypertension, cerebral vascular insufficiency, immune deficient states, cancer, aging- related disorders, reduced cardiopulmonary reserves and muscular fitness in athletics, high altitude climbing and exercise.
The invention provides method of improving sympathovagal balance in mammals by administering effective amounts of vitamin MK-7 or other vitamin K analogues and their derivatives.
A NOVEL, ECONOMIC AND ECO-FRIENDLY PROCESS FOR EXTRACTION OF MENAQUINONE-7 (VITAMIN K2-7) (2329/MUM/2007)
The present invention is related to an economical and eco-friendly process of supercritical fluid extraction, for the extraction and purification of vitamin K2-7 from the microbial fermentation broth, involving the sequential steps of (a) culturing and harvesting B. subtilis natto; (b) concentrating the broth containing K2-7 cells by cross flow procedure; (c) mixing the concentrate with an adsorbent; (d) subjecting mixture to supercritical fluid extraction (SFE) and (e) separation by expansion of gas/solute mixture.
PROCESS FOR IMPROVED RECOVERY OF FERMENTATION PRODUCTS FROM INTRACELLULAR AND EXTRACELLULAR PRESENCE (US2011/0201054A1)
The present invention increases yield of the target fermented molecules by spray drying the fermentation broth and reducing the process volume to nearly one tenth the original. Thus, none of the target molecules are lost and requirements of the solvent and the other conventional method process equipments and processing materials are reduced considerably. Product recovery is improved. A major saving in the waste water treatment offsets spray drying and offers better process economics.
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